How Does Protein Zero Assemble Compact Myelin?
نویسندگان
چکیده
منابع مشابه
Packing of Myelin Protein Zero
Senyon Choe P 0 and also by its association with apposing plasma membrane (Filbin et al., 1990). The self-adhesive prop-Structural Biology Laboratory erty of P0ex is essential in maintaining compact mem-The Salk Institute for Biological Studies brane adhesion. Consequently, mutations in P0 can lead La Jolla, California 92037 to various hypo-and dysmyelinating diseases. The detailed molecular st...
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Mutations found in the two major glycosylated transmembrane proteins of the PNS myelin, the peripheral myelin protein zero (P0) and peripheral myelin protein 22 (PMP22), have been independently associated with the most common hereditary demyelinating peripheral neuropathies. Genotype-phenotype correlations in humans and transgenic animals have provided functional evidence that P0 and PMP22 are ...
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ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/cells9081832